A passionate advocate who campaigned for change with METUPUK as a passionate advocate and worked with Secondary First secondary breast cancer charity to raise money and funds for SBC.
She leaves a husband and 3 sons.
We loved Mary who was feisty and not scared to voice her concerns.
Died 30.7.19
ER+ DX de novo with extensive liver mets April 2016 Epirubicin & cyclophosphamide Breast surgery & lymph clearance Radiotherapy Paclitaxel Gemcitabine & carboplatin Hysterectomy due to progression to ovaries Capecitabine Microwave ablation to liver Palbociclib & Fulvestrant Eribulin.
Private Treatment.
Died 23.2.20
ER+ PR+ HER2- De novo spread to many bones 3 years of letrozole (the last year addition of ibrance) Surgery to support skeleton - corpectomy and hip replacement and removal of primary in breast Current regime capecitabine for 18 months with addition of tamoxifen in the last 2 months Now have ESR1 mutation so hormone therapy may not work. Clinical Trial Fulvestrant This really concerns me as it reduces my future drug lines. NHS Treatment Progressed on clinical trial and liver failed.
Died 16.6.20
ER+ Primary breast cancer 2012 (clear scans) clinical trial, chemo, full mastectomy, RT. Stayed on Tamoxifen and given 5 years all clear March 2018. July 2018 dx with liver, bone and lung mets . Weekly paclitaxel. Scottish Health Service Treatment.
Died 29.6.20
Kadcyla which was finally approved in Wales May 20 Herceptin, cape and lapatinib (not accessible 3rd line in England) July 20 - brain mets and leptomenginal (brain lining) with lung progression to lungs and liver and vertebrae. WBRT.
Died 25.9.20
Welsh Health System Treatment
April 2006- ER Positive- 95%, PR Positive 75% and HER2 Negative. No lymph node involvement. Right breast wide local excision and sentinel node biopsy - adjuvant FEC chemo, adjuvant radiation therapy, adjuvant hormone therapy, tamoxifen 5 years plus Zoladex for 2 years. August 2016- disseminated liver metastasis with significant bone metastasis. Taxol Chemo weekly- 12 sessions September 2016- Denosumab every 12 weeks January 2017- Letrozole March 2018- Exemestane and Everolimus June 2018- Capecitabine June 2018-January 2020 progression in liver Capecitabine March 2020 Carboplatin - Palb2 mutation (now named BRACA3) May 2020 further progression to liver & new areas of brain & leptomeninges (Central Nervous System) & Given 4 months to live. June 2020 changed to Fulvestrant End June 2020 also awarded Abemaciclib compassionate grounds. August 2020: Stability of liver, bone, brain & leptomeninges. Blocked bile duct caused further complication & biliary drain inserted permanently. October 2020 Surgery to reverse the drain but even though surgery seemed to go OK there was progression of the liver.
Died 14.12.2020
NHS Treatment
ER+ PR+ HER2 – PBC Aug 2017 (aged 42) Mastectomy, full lymph node removal, chemo, RT tamoxifen exemestane, zoladex, cold capped. No symptoms but lump – initially thought haemangioma on spine dxd 2018 monitored & shrunk in response to exemestane.
ER+ PR+ HER2 + (triple positive) Bone Mets
January 2019 SBRT RT (Christie trial), then Docetaxel (x 3) Herceptin and Perjeta,
NEAD July 2019. Late-effects lymphedema (in remission). Denosumab & exemestane with zoladex;
oophorectomy Dec 2019.
ER- PR- HER2 – (TNBC)
new mass behind sternum/chest lymph nodes May 2020, chest pain, hospitalised with jugular blood clots/major vein blockage, emergency radiotherapy. Weekly paclitaxel 4-weekly denosumab
NHS Treatment
Died 18.2.21
